We have local Ethical Committee permission to enter patients into the following ongoing trials or studies; but others will be initiated:
1. Causes of Nephritis (local)
Gives us permission to take samples from patients with any renal disease and from relatives and other normal individuals, for research purposes, in order to study risk factors, aetiology, or prognosis.
Lead investigators: Dr R Phelps, Professor N Turner
2. Immunopathogenesis of Goodpasture’s disease (local)
Investigation of lymphocyte responses to Goodpasture antigen – sampling only BEFORE TREATMENT is initiated if at all possible.
Contacts: Dr R Phelps, Dr L Henderson, or Prof N Turner
3. Immunosuppression for membranous nephropathy
(Multicentre: Professor Peter Mathieson, Bristol)
For patients with deteriorating renal function over at least three months of observation and creatinine <300µmol/l.
Three limbs: chlorambucil/methylprednisolone; cyclosporin; supportive therapy only.
Local lead investigator: Professor N Turner
4. Genetics of Glomerulonehritis (Multicentre: Prof Andy Rees, Aberdeen)
Local contact: Professor N Turner
Stenting versus medical management alone where the ‘best’ treatment is uncertain. Local contact: Dr Ian Gillespie (Dept. Radiology) 5. Intevention in renal artery stenosis (ASTRAL: Multicentre)
6. Vasculitis Trials (ECYSVASTRIAL European Multicentre trials)
Various trials cover most new patients presenting with ANCA + MPA/WG involving the kidneys.
Local contact: Dr D Kluth
7. Lipid lowering in CRF (Multicentre: Dr Colin Baigent, Oxford)- SHARP
Enrolment complete.
Local contact: Dr C Swainson
8. Endothelin antagonists in CKD
Role in reducing proteinuria and effect on haemodynamics.
Contacts: Dr N Dhaun and Dr J Goddard
9. Trials initiated after August 2006 not listed here.
NOTE THAT ALL OF THESE TRIALS REQUIRE INFORMED CONSENT USING THE APPROVED FORMS BEFORE ENTRY INTO THE STUDIES. Acknowledgements: Last Updated in November 2006. This page last amended Thursday, November 30, 2006.
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